Tragically, when Quagmire went to Vermont to buy a present for James, Peter, Joe, Cleveland, and Brian, go over to Quagmire's to shave James as a prank, which backfired when Peter accidentally stabs James. In ' 420', Quagmire gets a new pet cat named James. Quagmire is currently a widower, although this is little hindrance to Quagmire, who delights in having intercourse with more girls without having to worry about cheating. She died after clutching onto Death's arm.
He was also briefly married to a maniac named Joan.
He was once arrested for peeping on Lois in the girls' bathroom in ' Blind Ambition'. He has pictures of Lois in his house, including on the inside of his closet door in ' Emission Impossible'. Unfortunately, he lost her and has since tried to fill the hole she left by having sex with women. Sometime in his past, Quagmire formed a relationship with Cheryl Tiegs, whom he loved.
